INSTITUTO DE CIÊNCIAS BIOMÉDICAS

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Excelência em Ensino e Pesquisa

Profa.Dra. Marinilce Fagundes dos Santos

Nome: Marinilce Fagundes dos Santos
Telefones: (11) 3091-7371 ou (11) 3091-7227
E-mail: mfsantos@usp.br
Currículo Lattes: http://lattes.cnpq.br/3538406078316217
Researcher ID: G-9548-2011
Scopus ID: 7402562388
Grupo de pesquisa do CNPq: Grupo de Adesão e Movimentação Celular

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Linha(s) de Pesquisa

Regulação da migração celular por micro RNAS: implicações no diabetes mellitus, cicatrização e câncer.

Mecanismos de sinalização envolvidos na hiperglicemia crônica: efeitos sobre a migração celular.

Emprego de nanotecnologia para aceleração da cicatrização de feridas crônicas em diabéticos – aplicação de anti-oxidantes utilizando nanopartículas lipídicas sólidas.

Principais Publicações

  1. Albuquerque JA, Lamers ML, Castiblanco-Valencia MM, Dos Santos M, Isaac L. Chemical chaperones curcumin and 4-phenylbutyric acid improve secretion of mutant factor H R127H by fibroblasts from a factor H-deficient patient. J Immunol. 2012 Sep 15;189(6):3242-8. doi: 10.4049/jimmunol.1201418.
  2. Lima MH, Caricilli AM, de Abreu LL, Araújo EP, Pelegrinelli FF, Thirone AC,
    Tsukumo DM, Pessoa AF, dos Santos MF, de Moraes MA, Carvalheira JB, Velloso LA, Saad MJ. Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One. 2012;7(5):e36974. doi: 10.1371/journal.pone.0036974.
  3. Vinolo MA, Rodrigues HG, Festuccia WT, Crisma AR, Alves VS, Martins AR, Amaral CL, Fiamoncini J, Hirabara SM, Sato FT, Fock RA, Malheiros G, dos Santos MF, Curi R. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E272-82.  doi: 10.1152/ajpendo.00053.2012.
  4. Rodrigues HG, Vinolo MA, Magdalon J, Vitzel K, Nachbar RT, Pessoa AF, dos Santos MF, Hatanaka E, Calder PC, Curi R. Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing. J Invest
    Dermatol. 2012 Jan;132(1):208-15. doi: 10.1038/jid.2011.265.
  5. Lamers ML, Almeida ME, Vicente-Manzanares M, Horwitz AF, Santos MF. High glucose-mediated oxidative stress impairs cell migration. PLoS One.
    2011;6(8):e22865. doi: 10.1371/journal.pone.0022865.
  6. Borges RM, Lamers ML, Forti FL, Santos MF, Yan CY. Rho signaling pathway and apical constriction in the early lens placode. Genesis. 2011 May;49(5):368-79. doi: 10.1002/dvg.20723.
  7. Biz MT, Marques MR, Crema VO, Moriscot AS, dos Santos MF. GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts. Cell Tissue Res. 2010 Jun;340(3):459-70. doi: 10.1007/s00441-010-0961-0.
  8. Silveira Corrêa TC, Massaro RR, Brohem CA, Taboga SR, Lamers ML, Santos MF, Maria-Engler SS. RECK-mediated inhibition of glioma migration and invasion. J Cell Biochem. 2010 May;110(1):52-61. doi: 10.1002/jcb.22472.
  9. Matté C, Stefanello FM, Mackedanz V, Pederzolli CD, Lamers ML, Dutra-Filho
    CS, Dos Santos MF, Wyse AT. Homocysteine induces oxidative stress, inflammatory infiltration, fibrosis and reduces glycogen/glycoprotein content in liver of rats. Int J Dev Neurosci. 2009 Jun;27(4):337-44. doi:
    10.1016/j.ijdevneu.2009.03.005
  10. Stefanello FM, Matté C, Pederzolli CD, Kolling J, Mescka CP, Lamers ML, de
    Assis AM, Perry ML, dos Santos MF, Dutra-Filho CS, Wyse AT. Hypermethioninemia provokes oxidative damage and histological changes in liver of rats. Biochimie. 2009 Aug;91(8):961-8. doi: 10.1016/j.biochi.2009.04.018.
  11. Sabino-Silva R, Freitas HS, Lamers ML, Okamoto MM, Santos MF, Machado UF. Na+-glucose cotransporter SGLT1 protein in salivary glands: potential involvement in the diabetes-induced decrease in salivary flow. J Membr Biol. 2009 Mar;228(2):63-9. doi: 10.1007/s00232-009-9159-3.
  12. Crema VO, Fossati AC, Hamassaki DE, Santos MF. Distribution of small Rho
    GTPases in the developing rat submandibular gland. J Mol Histol. 2008
    Oct;39(5):519-25. doi: 10.1007/s10735-008-9192-z.
  13. Costa EP, Del Debbio CB, Cintra LC, da Fontoura Costa L, Hamassaki DE, Santos MF. Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells. Toxicon. 2008 Aug 1;52(2):380-4. doi: 10.1016/j.toxicon.2008.04.165.
  14. Marques MR, Hajjar D, Franchini KG, Moriscot AS, Santos MF. Mandibular
    appliance modulates condylar growth through integrins. J Dent Res. 2008
    Feb;87(2):153-8.
  15. Lamers ML, Gimenes FA, Nogueira FN, Nicolau J, Gama P, Santos MF. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Matrix Biol. 2007 Sep;26(7):572-82.
  16. Crema VO, Hamassaki DE, Santos MF. Small Rho GTPases are important for acinus formation in a human salivary gland cell line. Cell Tissue Res. 2006
    Sep;325(3):493-500.
  17. Belmonte MA, Santos MF, Kihara AH, Yan CY, Hamassaki DE. Light-Induced
    photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1193-200.
  18. Santos-Bredariol AS, Belmonte MA, Kihara AH, Santos MF, Hamassaki DE. Small GTP-binding protein RhoB is expressed in glial Müller cells in the vertebrate retina. J Comp Neurol. 2006 Feb 20;494(6):976-85.
  19. Costa EP, Santos MF. Jararhagin, a snake venom metalloproteinase-disintegrin, stimulates epithelial cell migration in an in vitro restitution model. Toxicon. 2004 Dec 15;44(8):861-70.
  20. Santos-Bredariol AS, Santos MF, Hamassaki-Britto DE. Distribution of the
    small molecular weight GTP-binding proteins Rac1, Cdc42, RhoA and RhoB in the developing chick retina. J Neurocytol. 2002 Feb;31(2):149-59.
  21. Sebök A, Nusser N, Debreceni B, Guo Z, Santos MF, Szeberenyi J, Tigyi G.
    Different roles for RhoA during neurite initiation, elongation, and regeneration
    in PC12 cells. J Neurochem. 1999 Sep;73(3):949-60.
  22.  Santos MF, Viar MJ, McCormack SA, Johnson LR. Polyamines are important for attachment of IEC-6 cells to extracellular matrix. Am J Physiol. 1997 Jul;273(1 Pt 1):G175-83.
  23. Santos MF, McCormack SA, Guo Z, Okolicany J, Zheng Y, Johnson LR, Tigyi G. Rho proteins play a critical role in cell migration during the early phase of
    mucosal restitution. J Clin Invest. 1997 Jul 1;100(1):216-25.
  24. Zheng Y, Fischer DJ, Santos MF, Tigyi G, Pasteris NG, Gorski JL, Xu Y. The
    faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific
    guanine-nucleotide exchange factor. J Biol Chem. 1996 Dec 27;271(52):33169-72.