INSTITUTO DE CIÊNCIAS BIOMÉDICAS

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Excelência em Ensino e Pesquisa

Profa.Dra. Alison Colquhoun

Posição atual: Docente (RTP)
Doutorado: 1994
Orientador: Mestrado e Doutorado

Currículo Lattes

DESCRIÇÃO DA LINHA DE PESQUISA

Os principais interesses do laboratório incluem os mecanismos pelas quais os ácidos graxos individuais podem influenciar o metabolismo lipídico da célula tumoral, composição lipídica de membranas, metabolismo energético, morfologia da célula, migração celular e proliferação celular/morte celular.

Grupo de Biologia Molecular da Célula

PUBLICAÇÕES RELEVANTES

RAMOS, K. L.; COLQUHOUN, A. Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure. GLIA, v.43, 2003.

COLQUHOUN, A. Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. Biochimica et Biophysica Acta-Molecular And Cell Biology Of Lipids, v.1583, p.74 – 84, 2002. 

COLQUHOUN, A.; RAMOS, K. L.; SCHUMACHER, R. I. Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. Cell Biochemistry and Function, v.19, p.97 – 105, 2001.

RAMOS, K. L.; COLQUHOUN, A. Evidence for the involvement of polyunsaturated fatty acids in the regulation of long-chain acyl CoA thioesterases and peroxisome proliferation in rat carcinosarcoma. Cell Biochemistry and Function, v.19, p.1 – 9, 2001.

COLQUHOUN, A.; SCHUMACHER, R. I. Amma-linolenic and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcionsarcoma cells. Biochimica et Biophysica Acta-Molecular And Cell Biology Of Lipids, v.1533, p.207 – 219, 2001.

COLQUHOUN, A.; SCHUMACHER, R. I. Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid. Molecular and Cellular Biochemistry, v.218, p.13 – 20, 2001.

COLQUHOUN, A.; NEWSHOLME, E. A.Inhibition of human tumour cell proliferation by analogues of adenosine. Cell Biochemistry and Function, v.15, p.135 – 139, 1997.

COLQUHOUN, A.; NEWSHOLME, E. A.Aspects of glutamine metabolism in human tumour cells. Biochemistry and Molecular Biology International, v.41, p.583 – 596, 1997.

COLQUHOUN, A.; ALALUF, S.; BRADLEY, A.; GEMMELL, N.; GIBBS, G.; OSBORN, H. M. I.; HARWOOD, L.; NEWSHOLME, E. A. Novel monosaccharides as potent inhibitors of cell proliferation. Cell Biochemistry and Function, v.15, p.243 – 249, 1997.

BOARD, M.; COLQUHOUN, A.; NEWSHOLME, E. A. High Km glucose-phosphorylating (glucokinase) activities in a range of tumour cell lines and inhibition of rates of tumour growth by the specific enzyme inhibitor mannoheptulose. Cancer Research, v.55, p.3278 – 3285, 1995.