RESEARCH INTERESTS
Biology of digestive epithelia. Cell proliferation, differentiation, migration and death are being studied mainly in gastric and intestinal epithelia of developing rats. These epithelia pass through morphofunctional changes during development, specially during the period of weaning . The influence of changes in feeding patterns, together with hormonal, neuronal and functional maturation, on the cell cycle control are studied through cell and tissue kinetics, ultrastructural and immunohistochemical methods.
RELEVANT PAPERS
Daniela Ogias, Bianca Bitencourt, Alvares, E.P., Gama P. Corticosteroids induce the differential expression of TGFβ isoforms, receptors and signaling in the gastric mucosa of suckling rats. Regulatory Peptides, v.135, p.17-22, 2006.
Hernandes, L., Gama, P., Alvares, E. P. Ileal VIP submucous neurons: confocal study of the area enlargement induced by myenteric denervation in weanling rats. Regulatory Peptides. , v.117, n.1, p.69-72, 2004.
Sá, E. R. A., Jordão, L. R., Takahashi, C. A., Alvares, E. P., Gama, P. Ontogenic expression of TGF beta1, 2, 3 and its receptors in the rat gastric mucosa.. Developmental Dynamics. USA: , v.227, p.450-457, 2003.
Buttow, N. C., Zucoloto, S., Espreafico, E. M., Gama, P., Alvares, E. P. Substance P enhances the neuronal area and epithelial cell proliferation after colon denervation in rats. Digestive Diseases and Sciences. , v.48, n.10, p.2069-2076, 2003.
Gama, P., Alvares, E. P. Localization of LHRH binding sites in the gastric mucosa of suckling rats. Anatomical Record. , v.264, p.43-50, 2001.
Gama, P., Alvares, E.P.. Localization of Luteinizing hormone realeasing hormone binding sites in the gastric mucosa of suckling rats. Anatomical Record 264: 43-50, 2001.
Gama, P., Alvares, E. P. Early weaning and prolonged nursing induce changes in cell proliferation in the gastric epithelium of developing rats. J. Nutr.130: 2594-2598, 2000.
Gama, P., Goldfeder, E.M., Moraes, J.C.B., Alvares, E.P.. Cell proliferation and death in the gastric epithelium of developing rats after glucocorticoids treatment. Anatomical Record 260 (3): 213-221, 2000.
Hernandes, L.; Zucoloto, S.; Alvares, E.P. Effect of myenteric denervation on intestinal epithelium proliferation and migration of suckling and weanling rats. Cell Proliferation 33:127-138, 2000.
Gama, P., Alvares, E. P. Corticosterone treatment inhibits the cell proliferation of the gastric epithelium in suckling rats. J. Gastroenterol.33 (1): 32-8, 1998.
