Posição atual: Professor Doutor
Doutorado: 2006
Orientador:
Descrição da Linha de Pesquisa
O enfoque da pesquisa, no nosso laboratório, é o papel de elementos da Matriz Extracelular na Biologia Tumoral. O estudo é baseado na análise dos componentes do microambiente tumoral com destaque para o papel de metaloproteases da família ADAMTS no comportamento de neoplasias de mama e ovário. Endereçamos problemas biológicos valendo-se de métodos morfológicos, bioquímicos e de biologia molecular.
Publicações
Siqueira AS; Carvalho MR; Monteiro AC; Freitas VM; Jaeger RG; Pinheiro JJ. Matrix metalloproteinases, TIMPs and growth factors regulating ameloblastoma behaviour. Histopathology 57:128-37, 2010.
Nascimento CF; Gama-De-Souza LN; Freitas VM; Jaeger RG Role of MMP9 on invadopodia formation in cells from adenoid cystic carcinoma. Study by laser scanning confocal microscopy. Microsc Res Tech. 73:99-108, 2010.
Boggio RF; Freitas, V M; Cassiola FM; Urabayashi, M; Machado-Santelli, GM. Effect of a calcium channel blocker (verapamil) on the morphology, cytoskeleton and collagenase activity of human skin fibroblasts. Burns 2010 [Epub ahead of print].
de Lima, MDM; Marques, Y; de Melo Alves Jr., Sérgio; Freitas VM; Soares FA; de Araújo, VC; Pinto Jr., DS; Mantesso, A . MDM2, P53, P21WAF1 and pAKT protein levels in genesis and behaviour of adenoid cystic carcinoma? Journal of Cancer Epidemiology and Prevention 33: 142-146, 2009.
Gama-de-Souza LN; Cyreno-Oliveira E; Freitas VM; Melo, ES; Vilas-Boas, VF; Moriscot, AS; Jaeger, RG. Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin. Matrix Biol. 27:402-19, 2008.
Jaeger, RG; Scarabotto-Neto, N; Azambuja Jr, N; Freitas, VM. Secretion of collagen I and tenascin is modulated by laminin-111 in 3D culture of human adenoid cystic carcinoma cells. Int J Exp Pathol. 89:98-105, 2008.
Freitas, VM; Rangel, M; Bisson, LF; Jaeger, RG; Machado-Santelli, GM. The geodiamolide H, derived from Brazilian sponge Geodia corticostylifera, regulates actin cytoskeleton, migration and invasion of breast cancer cells cultured in three- dimensional environment. J Cell Physiol. 216:583-94, 2008.
Freitas, VM; Vilas-Boas, VF; Pimenta, DC; Loureiro, V; Juliano, MA; Carvalho, MR; Pinheiro, JJ; Camargo, AC; Moriscot, AS; Hoffman, MP; Jaeger, RG. SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway . Am J Pathol. 171:124-38, 2007.
Morais Freitas, V; Nogueira da Gama de Souza, L; Cyreno Oliveira, E; Furuse, C; Cavalcanti de Araújo, V; Gastaldoni Jaeger, R. Malignancy-related 67kDa laminin receptor in adenoid cystic carcinoma. Effect on migration and beta-catenin expression. . Oral Oncol. 43:987-98, 2007.
Freitas, VM; Scheremeta, B; Hoffman, MP; Jaeger, RG. Laminin-1 and SIKVAV a laminin-1-derived peptide, regulate the morphology and protease activity of a human salivary gland adenoid cystic carcinoma cell line . Oral Oncol. 40:483-9, 2004.
Pinheiro, JJ; Freitas, VM; Moretti, AI; Jorge, AG; Jaeger, RG. Local invasiveness of ameloblastoma. Role played by matrix metalloproteinases and proliferative activity. Histopathology 45:65-72, 2004.
Freitas, VM; Jaeger, RG. The effect of laminin and its peptide SIKVAV on a human salivary gland adenoid cystic carcinoma cell line. Virchows Archiv 441: 569-576, 2002.
Franca, CM; Jaeger, RG; Freitas, VM; Araujo, NS; Jaeger M. Effect of N-CAM on in vitro invasion of human adenoid cystic carcinoma cells. Oral Oncol 37: 638-642, 2001.
