INSTITUTO DE CIÊNCIAS BIOMÉDICAS

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Excelência em Ensino e Pesquisa

Dr. Dânia Emi Hamassaki

HomeAbout the DepartmentFacultyDr. Dânia Emi Hamassaki

Nome: Dânia Emi Hamassaki
Telefone: 3091-7230 / 7219
E-mail: dania@usp.br
Currículo Lattes: http://lattes.cnpq.br/6170942801660703
Researcher ID: http://www.researcherid.com/rid/C-4455-2012

Linha(s) de Pesquisa:

Retinopatia diabética, descolamento de retina, buraco macular e retinose pigmentar são doenças que afetam a retina e/ou o vítreo e levam à perda parcial ou total da visão, sem que existam terapias eficazes para casos complexos em várias delas. Utilizando modelos in vivo e in vitro e diferentes metodologias,nosso laboratório tem como objetivo investigar os mecanismos que levam à degeneração da retina e sua regeneração via células-tronco/ progenitoras endógenas; 2) alterações da constituição e propriedades físicas do vítreo durante o envelhecimento e em doenças da interface vítreo-retinianas.
Com esses estudos esperamos contribuir para o desenvolvimento de novas terapias para a prevenção e tratamento de doenças ainda incuráveis.

Principais Publicações:

  1. Silva KC, Rosales MA, Hamassaki DE, Saito KC, Faria AM, Ribeiro PA, Faria JB, Faria JM. Green tea is neuroprotective in diabetic retinopathy. Invest Ophthalmol Vis Sci. 54(2):1325-36, 2013.
  2. Baldo MVC, Hamassaki DE, Ventura DS. Visão. In: Margarida de Mello Aires. (Org.). Fisiologia. 4aed. Guanabara Koogan, 2012, p. 310-330.
  3. Kihara AH, Santos TO, Osuna-Melo EJ, Paschon V, Vidal KS, Akamine PS, Castro LM, Resende RR, Hamassaki DE, Britto LR. Connexin-mediated communication controls cell proliferation and is essential in retinal histogenesis. Int J Dev Neurosci. 28(1):39-52, 2010.
  4. Kihara AH, Paschon V, Cardoso CM, Higa GS, Castro LM, Hamassaki DE, Britto LR. Connexin36, an essential element in the rod pathway, is highly expressed in the essentially rodless retina of Gallus gallus. J. Comp. Neurol. 512 (5): 651-63, 2009.
  5. Belmonte MA, Santos MF, Kihara A, Yan, CYI, Hamassaki DE . Light-induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Invest Ophthalmol Vis Sci. 47: 1193-1200, 2006.
  6. Santos-Bredariol AS, Belmonte MA, Kihara AH, Santos MF and Hamassaki DE. The small GTP-binding protein RhoB in glial Muller cells in the vertebrate retina. J. Comp. Neurol 494: 976-85, 2006.
  7. Kihara AH, Castro LM, Belmonte MA, Yan CYI, Moriscot AS, and Hamassaki DE. Expression of connexins 36, 43 and 45 during postnatal development of the mouse retina. J. Neurobiol. 66(13):1397-410, 2006 (capa do fascículo).
  8. Lima AG, Britto LR, Hossokawa NM, Hamassaki-Britto DE. Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice. Neurosci Lett. May 15;342(1-2):9-12, 2003.
  9. Santos-Bredariol AS, Santos MF and Hamassaki-Britto DE. Distribution of the small molecular weight GTP-binding proteins Rac1, Cdc42, RhoA and RhoB in the developing chick retina. J. Neurocytol. 31: 149-159, 2002 (capa do fascículo).
  10. Hamassaki-Britto DE, Hermans-Borgmeyer I, Heinemann S, and Hughes TE.  Expression of glutamate receptor genes in the mammalian retina: the localization of GluR1 through GluR7 mRNAs. J. Neurosci. 13: 1888-1898, 1993.

RESEARCH INTERESTS

The main interest of our laboratory is the functional organization of the vertebrate retina, and especially the distribution of neurotransmitters and their receptors. Immunohistochemistry, “in situ” hybridization, pathway tracers, PCR and laser microdissection have been used to characterize the different retinal cell types in terms of their neurochemical content, morphology, and projections to central visual pathways. These studies may contribute with new insights about the retinal circuitry and the visual processing in vertebrates.

RELEVANT PAPERS

Santos-Bredariol AS, Belmonte MA, Kihara AH, Santos MF, Hamassaki D.E. Small GTP-binding protein RhoB is expressed in glial muller cells in the vertebrate retina. J Comp Neurol., 20;494(6):976-85, 2006.

Belmonte MA, Santos MF, Kihara AH, Yan CY, Hamassaki D.E. Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Invest Ophthalmol Vis Sci., 47(3):1193-200, 2006

Kihara AH, Mantovani de Castro L, Moriscot AS, Hamassaki D.E. Prolonged dark adaptation changes connexin expression in the mouse retina. J Neurosci Res., 22; 2006.

Lima, A.G., Britto, L.R.G., Hossokawa, N.M. and Hamassaki-Britto, D.E. Static, but not optokinetic visual stimuli induce Fos expression in the retina and brain of retinal degeneration mice. Neurosci Lett. 342: 9-12, 2003.

Santos-Bredariol, A.S., Santos, M.F. and Hamassaki-Britto, D.E. Distribution of the small molecular weight GTP-binding proteins Rac1, Cdc42, RhoA and RhoB in the developing chick retina. J. Neurocytol. 31: 149-159, 2002.

Bredariol, A.S.S. and Hamassaki-Britto, D.E. Development of ionotropic glutamate receptors in the chick retina. J. Comp. Neurol. 441: 58-70, 2001.

Hamassaki-Britto, D.E., Hermans-Borgmeyer, I., Heinemann, S., and Hughes, T.E. Expression of glutamate receptor genes in the mammalian retina: the localization of GluR1 through GluR7 mRNAs. J. Neurosci. 13: 1888-1898, 1993.