Position held: Associate Professor
PhD: 1998- Columbia University
DESCRIÇÃO DA LINHA DE PESQUISA
The focus of the research in our laboratory is to determine the molecular mechanisms that drive embryogenesis. In particular, we are interested in events that determine and define the nervous system. For this purpose, we used as an experimental model the chicken embryo neural tube and lens. The chicken embryo is one of the classic models of embryology that allows us to observe and manipulate various embryological events. Moreover, in this animal model both the neural tube and eye are easily accessible region sof the central nervous system. Thus, we perform in ovo embryonic surgery and manipulate genetic pathways to and gene function during early neurogenesis and lens morphogenesis.
PUBLICATION LIST
- A detailed description of an economical setup for electroporation of chick embryos in ovo Borges, R. M., Horne, J. H., Melo, a, Vidal, J. T., Vieceli, F. M., Melo, M. O., Kanno, T. Y. N., Fraser, S. E., and Yan, C. Y. I. (2013). Braz. J. Med. Biol. Res. 46, 752–757.
- The transcription factor chicken Scratch2 is expressed in a subset of early postmitotic neural progenitors.Vieceli, F. M., Simões-Costa, M., Turri, J. A., Kanno, T., Bronner, M., Yan, C. Y. I., (2013). Gene Expr. Patterns 13, 189–196.
- Rho signaling pathway and apical constriction in the early lens placode. Borges RM, Lamers, ML, Forti FL, Santos MF, Yan, CYI (2011) Genesis. 49, 368-379 .
- Samba, a Xenopus hnRNP expressed in neural and neural crest tissues. Yan, CYI, Skourides P, Chang C, Hemmati-Brivanlou A. Developmental Dynamics (2009) 238(1):204-9 .
- An immunohistochemical characterization of the chick peripheral retina and the ciliary marginal zone. Penhas de Lima I, Hamassaki DE, Yan CYI (2007) The Brazilian Journal of Medical and Biological Research 40(11):1455-64.
- Expression pattern of Wnt ligands during chick eye development. Rossi E, Siwiec F, Yan CYI (2007) The Brazilian Journal of Medical and Biological Research 40(10):1333-1338.
Capítulo de livros
- Neural Induction K.L de Almeida, J. Garcia e C.Y. Irene Yan do livro Perspectives of Stem Cells, ed Henning Ulrich Editora Springer Dordresch ISBN 978-90-481-3374-1
- Gene expression in embryonic neural development and stem cell differentiation. Yan, C. Y. I., Vieceli, F. M., Kanno, T. Y., O, J. A., and Turri, J. A. , Hayashi, M.F. (2012). In: Embryogenesis ISBN 978-953-51-0466-7, ed. K. Sato, 249–268.
