RESEARCH INTERESTS
The main points of interest in the lab include the mechanisms by which individual fatty acids can influence tumour cell lipid metabolism, membrane composition, energy metabolism, cell morphology, cell migration and cell proliferation/cell death.
RELEVANT PAPERS
RAMOS, K. L., COLQUHOUN, A. Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure. GLIA. , v.43, No Prelo, 2003.
COLQUHOUN, A. Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumour. Biochimica et Biophysica Acta-Molecular And Cell Biology Of Lipids. , v.1583, p.74 – 84, 2002.
COLQUHOUN, A., RAMOS, K. L., SCHUMACHER, R. I. Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. Cell Biochemistry and Function. , v.19, p.97 – 105, 2001.
RAMOS, K. L., COLQUHOUN, A. Evidence for the involvement of polyunsaturated fatty acids in the regulation of long-chain acyl CoA thioesterases and peroxisome proliferation in rat carcinosarcoma. Cell Biochemistry and Function. , v.19, p.1 – 9, 2001.
COLQUHOUN, A., SCHUMACHER, R. I. Gamma-linolenic and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcionsarcoma cells. Biochimica et Biophysica Acta-Molecular And Cell Biology Of Lipids. , v.1533, p.207 – 219, 2001.
COLQUHOUN, A., SCHUMACHER, R. I. Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid. Molecular and Cellular Biochemistry. , v.218, p.13 – 20, 2001.
COLQUHOUN, A., NEWSHOLME, E. A. Inhibition of human tumour cell proliferation by analogues of adenosine. Cell Biochemistry and Function. , v.15, p.135 – 139, 1997.
COLQUHOUN, A., NEWSHOLME, E. A. Aspects of glutamine metabolism in human tumour cells. Biochemistry and Molecular Biology International. , v.41, p.583 – 596, 1997.
COLQUHOUN, A., ALALUF, S., BRADLEY, A., GEMMELL, N., GIBBS, G., OSBORN, H. M. I., HARWOOD, L., NEWSHOLME, E. A. Novel monosaccharides as potent inhibitors of cell proliferation. Cell Biochemistry and Function. , v.15, p.243 – 249, 1997.
BOARD, M., COLQUHOUN, A., NEWSHOLME, E. A. High Km glucose-phosphorylating (glucokinase) activities in a range of tumour cell lines and inhibition of rates of tumour growth by the specific enzyme inhibitor mannoheptulose. Cancer Research. , v.55, p.3278 – 3285, 1995.
